Grant: Project Grant
Université de Sherbrooke
$1,009,800.00
Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking
FY 2023-24
Summary
The Galphas (Gas) subunit is classically known to act as a molecular switch that relays extracellular signals from G protein-coupled receptors (GPCRs) located on plasma membranes to downstream effectors. Gas has been studied for more than thirty years and its
structure and functions are well characterized. Although it was believed that all functional aspects of this protein had been elucidated, we recently found that Gas has the capacity to bind ubiquitin and that it is also ubiquitinated. We believe that ubiquitin is thus a major regulatory signal for Gas functions. Therefore, the overall objective of this proposal is to outline this novel mode of regulation of Gas and its effect in receptor trafficking and signaling.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
489527
Name
Lavoie Christine
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Pharmacology & Toxicology
Projecttitle
Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$1,009,800
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Endosomal Sorting; G Alpha S; G Protein Coupled Receptor (Gpcr); Heart-Cardiomyocytes; Heterotrimeric G Proteins; Intracellular Trafficking; Signal Transduction; Ubiquitin; Ubiquitin Interacting Motif (Uim)
Abstract
The Galphas (Gas) subunit is classically known to act as a molecular switch that relays extracellular signals from G protein-coupled receptors (GPCRs) located on plasma membranes to downstream effectors. Gas has been studied for more than thirty years and its
structure and functions are well characterized. Although it was believed that all functional aspects of this protein had been elucidated, we recently found that Gas has the capacity to bind ubiquitin and that it is also ubiquitinated. We believe that ubiquitin is thus a major regulatory signal for Gas functions. Therefore, the overall objective of this proposal is to outline this novel mode of regulation of Gas and its effect in receptor trafficking and signaling.
Competitiondate
202309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Lavoie, Christine
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,009,800~ $0~
