Grant: Project Grant
University of British Columbia
$896,580.00
Traffic-Related Air Pollution, Inhaled Corticosteroids and Host Defence Response in COPD
FY 2021-22
Summary
Facts have shown that people made sick by smoking for years are made worse by bad air outside. They also often need to go to the hospital if they get a bug. One of the main drugs they take for this sickness (inhaled steroid) may change their lungs in ways that make it harder to deal with bugs, especially if they breathe in bad air. If so, this could make them need to go to the hospital more often. On the other hand, the drug (inhaled steroid) seems to help some
people avoid going to hospital. We want to understand if this drug, together with bad air, makes people with lung sickness have more problems if they get a bug. To do this, we will run a study where people breathe in fresh air or bad air while taking the drug or not. We will look at the facts from this study to see if we can know how bad air and the drug together might make them get more bugs and need to go to the hospital more often.
Department
Program
Project Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
462107
Name
Carlsten Christopher
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Respiratory System
Projecttitle
Traffic-Related Air Pollution, Inhaled Corticosteroids and Host Defence Response in COPD
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$896,580
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Air Pollution; Anti-Microbial Peptides/Proteins (Amps); Chronic Obstructive Pulmonary Disease (Copd); Inhaled Corticosteroid (Ics); Innate Immunity
Abstract
Facts have shown that people made sick by smoking for years are made worse by bad air outside. They also often need to go to the hospital if they get a bug. One of the main drugs they take for this sickness (inhaled steroid) may change their lungs in ways that make it harder to deal with bugs, especially if they breathe in bad air. If so, this could make them need to go to the hospital more often. On the other hand, the drug (inhaled steroid) seems to help some
people avoid going to hospital. We want to understand if this drug, together with bad air, makes people with lung sickness have more problems if they get a bug. To do this, we will run a study where people breathe in fresh air or bad air while taking the drug or not. We will look at the facts from this study to see if we can know how bad air and the drug together might make them get more bugs and need to go to the hospital more often.
Competitiondate
202203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Carlsten, Christopher; Mookherjee, Neeloffer
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $896,580~ $0~
