Grant: CIHR Fellowship

Since its discovery in 1961 as a key step in the transmission of genetic information, gene transcription has frequently been in the spotlight of scientific and medical research. This interest is driven by the complex and varied nature of diseases associated with the dysregulation of the transcription process. In our body, gene transcription is carried out by a protein complex known as RNA polymerase II (RNAPII). This complex is responsible for copying the genetic information contained in DNA into RNA, which then provides the necessary instructions for protein synthesis essential for all physiological processes. Indeed, the activity of RNAPII must be finely regulated to ensure optimal transfer of genetic information, which involves small chemical modifications known as phosphorylation. Dysfunctions in the phosphorylation process of RNAPII are linked to various diseases, including certain cancers. To date, however, we know very little about the role of these phosphorylation events. The objective of this project is to understand the functional significance of specific RNAPII modifications in the transcriptional process. This research is not only crucial for a fundamental understanding of transcriptional regulation, but also for its potential implications in pathological contexts. By understanding these mechanisms, researchers can develop new therapeutic strategies or improve existing treatments.