Grant: Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
University of British Columbia
$341,259.00
Modulation of HIV provirus expression to eliminate latently infected cells
FY 2013-14
Summary
Contrary to common belief, AIDS and HIV infection remains a significant problem for our society. Decades of extensive research has produced combinations of drugs that can stop growth of the virus and suppress the disease we call AIDS. But, unfortunately, these drugs are only a short-term solution, because they do not cure the infection, and they are unaffordable for most infected people in the world. People living with HIV, taking these current drugs, still have the virus in their body because they have cells wherein the virus is hiding, and consequently must continue their medication throughout the remainder of their lives. Unfortunately, many people become intolerant towards treatment after some time, and also strains of HIV are beginning to emerge that are resistant to treatment. The research we describe in this proposal is designed to develop new classes of drugs that can completely eliminate HIV from infected people, with the goal of ultimately providing a cure for AIDS.
Department
Program
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
297399
Name
Sadowski Ivan J
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Modulation of HIV provirus expression to eliminate latently infected cells
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$341,259
Cihrequipment2
$0
Programname2
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Keyworddelim
Apoptosis; Cytotoxicity; Hiv; Lariat Peptide Inhibitors; Latency; Primary Cells; Small Molecule Inhibitors; T Cell Signaling; T Cells
Abstract
Contrary to common belief, AIDS and HIV infection remains a significant problem for our society. Decades of extensive research has produced combinations of drugs that can stop growth of the virus and suppress the disease we call AIDS. But, unfortunately, these drugs are only a short-term solution, because they do not cure the infection, and they are unaffordable for most infected people in the world. People living with HIV, taking these current drugs, still have the virus in their body because they have cells wherein the virus is hiding, and consequently must continue their medication throughout the remainder of their lives. Unfortunately, many people become intolerant towards treatment after some time, and also strains of HIV are beginning to emerge that are resistant to treatment. The research we describe in this proposal is designed to develop new classes of drugs that can completely eliminate HIV from infected people, with the goal of ultimately providing a cure for AIDS.
Competitiondate
201309
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Sadowski, Ivan J
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $341,259~ $0~
