Grant: Operating Grant
University of Toronto
$652,287.00
Decoding C2H2 zinc fingers
FY 2012-13
Summary
One of the largest classes of proteins in the human genome - encompassing ~700 of the ~22,000 known human protein-coding genes - is the C2H2 zinc fingers. These proteins are primarily believed to bind to specific DNA sequences and thereby regulate the expression, accessibility, and topology of the genome. Most, however, are simply uncharacterized. We propose to study the functions of proteins in the C2H2 class by exploring what sequences they bind, whether they bind DNA, RNA, or protein, and how the amino-acid sequence of the C2H2 zinc finger proteins relates to their biochemical and genetic functions.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
279205
Name
Hughes Timothy R
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genomics: Systems and computational biology
Projecttitle
Decoding C2H2 zinc fingers
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$652,287
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Computational Biology; Dna Motifs; Genomics; Repetitive Elements; Retroviruses; Transcription Factors
Abstract
One of the largest classes of proteins in the human genome - encompassing ~700 of the ~22,000 known human protein-coding genes - is the C2H2 zinc fingers. These proteins are primarily believed to bind to specific DNA sequences and thereby regulate the expression, accessibility, and topology of the genome. Most, however, are simply uncharacterized. We propose to study the functions of proteins in the C2H2 class by exploring what sequences they bind, whether they bind DNA, RNA, or protein, and how the amino-acid sequence of the C2H2 zinc finger proteins relates to their biochemical and genetic functions.
Competitiondate
201303
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Hughes, Timothy R
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $652,287~ $0~
