Grant: Operating Grant

The skeleton is very important for daily activities such as walking and posture. It is hence important for quality of life for an individual. Cancers that primarily arise within the bone or that have spread to the bone can disrupt the architecture of the bone by altering the balance of bone formation and remodeling leading to overall bone destruction, pain and fracture. Giant Cell Tumour of bone is an aggressive bone tumour that typically affects young adults and requires extensive surgery for cure. Dr. Ghert's lab has done extensive research exploring the mechanisms involved in the destruction of bone by these tumours. The overall goal of Dr. Ghert's research is to develop effective targeted molecular treatment for cancers that affect bone in which bone formation and destruction are imbalanced.