Grant: Research Tools and Instruments - Category 1 (<$150,000)
Queen's University
$61,124.00
Ultrasound system with high frame rate and dynamic focus for prostate cancer diagnosis and intervention
FY 2008-09
Summary
Prostate cancer is the second leading cancer-related cause of death in North America. Every year about 240,000 new cases are diagnosed and more than 30,000 men die from prostate cancer. Our group has discovered that time series analysis of ultrasound data can provide valuable pathological information about prostatic malignancies. In previously resected prostate cancer specimens, we achieved over 90% accuracy in localizing cancerous tissues. Our current goal is to validate our approach with in vivo studies.
In a pilot study, we observed that physiological motions due to respiration and blood flow can lead to inconclusive interpretation of ultrasound data. This effect would be eliminated by using a system that can capture images faster than the rate at which dominant physiological motions occur. The ultrasound system with a high frame rate requested here is unique in that it can provide this capability. We would be able to acquire images that are literally free of physiological motion artifacts. This system is also unique in that it provides dynamic focusing which will allow the precise identification of anatomical substructures and of the deployment of therapeutic agents in the prostate. This capability will be of paramount importance in the advancement of minimally invasive prostate cancer interventions.
If successful, we will be the world's first research group to demonstrate the feasibility of accurate ultrasound based biopsy and brachytherapy. In the short term, we will be able to make a significant contribution to the management of prostate cancer that can be generalized to other types of cancer such as liver and ovarian cancers. In the long term, we will be able to integrate our prostate cancer biopsy and brachytherapy research into a preeminent, unified platform for the diagnosis and treatment of prostate cancer.
We provide an interdisciplinary, collaborative environment for training highly qualified personnel (HQP) in innovative computational techniques while advancing medical knowledge. The investigators are (co-)supervising more than thirty HQP whose training will be augmented as a direct result of this equipment.
Program
Research Tools and Instruments - Category 1 (<$150,000)
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
375097-2009
Name nom
Abolmaesumi, Purang
Department département
Computing, School of
Organization id
29
Institution établissement
Queen's University
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2008
Competition year année de concours
2009
Award amount
61124
Program id
EQPEQ
Program nane en
Research Tools and Instruments - Category 1 (<$150,000)
Program name fr
Outils et instruments de recherche - catégorie 1 (<150 000$)
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
331
Committee name en
Computing and Information Sciences - B
Committee name fr
Informatique - B
Area of application code
802
Area of application group en
Information and communication services
Area of application group fr
Services d'information et de télécommunications
Area of application en
Information systems and technology
Area of application fr
Systèmes d'information et technologie de l'information
Research subject code
2708
Research subject group en
Information technology
Research subject group fr
Technologie de l'information
Research subject en
Image processing
Research subject fr
Traitement des images
Partie
1
Nb partie
1
Application title
Ultrasound system with high frame rate and dynamic focus for prostate cancer diagnosis and intervention
Keyword
NA
Application summary
Prostate cancer is the second leading cancer-related cause of death in North America. Every year about 240,000 new cases are diagnosed and more than 30,000 men die from prostate cancer. Our group has discovered that time series analysis of ultrasound data can provide valuable pathological information about prostatic malignancies. In previously resected prostate cancer specimens, we achieved over 90% accuracy in localizing cancerous tissues. Our current goal is to validate our approach with in vivo studies.
In a pilot study, we observed that physiological motions due to respiration and blood flow can lead to inconclusive interpretation of ultrasound data. This effect would be eliminated by using a system that can capture images faster than the rate at which dominant physiological motions occur. The ultrasound system with a high frame rate requested here is unique in that it can provide this capability. We would be able to acquire images that are literally free of physiological motion artifacts. This system is also unique in that it provides dynamic focusing which will allow the precise identification of anatomical substructures and of the deployment of therapeutic agents in the prostate. This capability will be of paramount importance in the advancement of minimally invasive prostate cancer interventions.
If successful, we will be the world's first research group to demonstrate the feasibility of accurate ultrasound based biopsy and brachytherapy. In the short term, we will be able to make a significant contribution to the management of prostate cancer that can be generalized to other types of cancer such as liver and ovarian cancers. In the long term, we will be able to integrate our prostate cancer biopsy and brachytherapy research into a preeminent, unified platform for the diagnosis and treatment of prostate cancer.
We provide an interdisciplinary, collaborative environment for training highly qualified personnel (HQP) in innovative computational techniques while advancing medical knowledge. The investigators are (co-)supervising more than thirty HQP whose training will be augmented as a direct result of this equipment.
