Grant: Operating Grant
University of British Columbia
$649,994.00
Basis for Calcium Regulation of Cardiac Sodium Channels
FY 2011-12
Summary
Heart failure impacts the lives of more than 400,000 Canadians, with nearly 50,000 plus new cases diagnosed each year in our aging population. Nearly the half of these heart failure patients will die unexpectedly from electrical instability in the heart that leads to sudden death. The exact causes of sudden death are not known but it is generally appreciated that changes in the electrical activity in the heart through a process called 'remodeling' leads to changes in the ability of the heart beat properly. Our research will contribute to the understanding on the electrical system in the heart and will provide new information of how this electrical system will respond to the changing environment in the failing heart. Moreover, there are rare inherited diseases that impact the same types of electrical signaling in the heart that occur in failing hearts, and our study will address the basis for these diseases with the goal of developing new drugs for the treatment of all types of cardiac disturbances.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
239445
Name
Ahern Christopher A
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - A: Cells and Tissues
Projecttitle
Basis for Calcium Regulation of Cardiac Sodium Channels
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$649,994
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Biochemistry; Calcium Regulation; Cardiac Arrhythmia; Isothermal-Titration Caloimetry; Long Qt Type 3 Arrhythmia; Patch-Clamp Electrophysiology; Site-Direted Mutagenesis; Voltage-Gated Ion Channels; X-Ray Crystalography
Abstract
Heart failure impacts the lives of more than 400,000 Canadians, with nearly 50,000 plus new cases diagnosed each year in our aging population. Nearly the half of these heart failure patients will die unexpectedly from electrical instability in the heart that leads to sudden death. The exact causes of sudden death are not known but it is generally appreciated that changes in the electrical activity in the heart through a process called 'remodeling' leads to changes in the ability of the heart beat properly. Our research will contribute to the understanding on the electrical system in the heart and will provide new information of how this electrical system will respond to the changing environment in the failing heart. Moreover, there are rare inherited diseases that impact the same types of electrical signaling in the heart that occur in failing hearts, and our study will address the basis for these diseases with the goal of developing new drugs for the treatment of all types of cardiac disturbances.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ahern, Christopher A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $649,994~ $0~
