Grant: Building the Foundation of the JPIAMR VRI

InFACT - the International Forum for Acute Care Trialists - is an established platform to promote international collaboration in acute care research. The AMRIC (Antimicrobial Resistance in Intensive Care) proposal will use the InFACT infrastructure and collaboration network to spearhead a global acute care initiative for research on antimicrobial resistance. InFACT was established by independent investigator-led clinical research groups and academic research consortia to provide a mechanism to build international collaboration, to address common needs, and to raise the profile of investigator drivenacute care research with researchers, policymakers, funders and the general public. Currently, there are 35 member networks. These represent every continent and income-grouping on the planet and share a common goal of advancing science and building research capacity. InFACT member networks are the leading research networks in critical care, with embedded mentoring and knowledge exchange activities. AMRIC, using the InFACT model and its pre-existing collaborations, will scale-up a plan for data sharing on the sources, burden, modifiable risk factors, and impact of antimicrobial resistance in acute care settings around the world. Through a recently funded and established mapping platform (ACCESS-MAPS, co-investigator Wallace) and a large team of motivated investigators, we will implement a plan for clinical and microbiologic data sharing for determining the scale of the problem in acute care settings globally. We have recently conducted scoping reviews on the subject through prior JPIAMR support; this proposal will allow for building plans for implementation of the findings and coordinating the scaling-up of prospective data collection.