Grant: Travel Awards - Institute Community Support
Université Laval
$1,000.00
Association Of Sex And Low-Flow With Survival After Aortic Valve Replacement For Severe Aortic Stenosis And Preserved Left Ventricular Ejection Fraction
FY 2019-20
Summary
Discordant grading is frequent with aortic stenosis (AS) and preserved LVEF. Our study shows that in patients with low-flow, those with high-gradient had worse outcome than those with low-gradient, underscoring the need for early intervention (i.e., before gradient reaches 40 mmHg). Sex-differences have been observed in valve and myocardium in AS, but the guidelines' threshold defining low-flow is the same for men and women (35 ml/m2). The use of sex-specific thresholds for defining low-flow (32 ml/m2 for women and 40 ml/m2 for men) predicts mortality in both sexes and enhances risk stratification, outperforming the guidelines threshold of 35 ml/m2.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
409262
Name
Guzzetti Ezequiel
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Institute of Circulatory and Respiratory Health
Projecttitle
Association Of Sex And Low-Flow With Survival After Aortic Valve Replacement For Severe Aortic Stenosis And Preserved Left Ventricular Ejection Fraction
Programtype2
Undefined
Orgnameinp2
Université Laval
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Aortic Stenosis; Aortic Valve Replacement; Mortality; Paradoxical Low Flow Aortic Stenosis; Sex Differences
Abstract
Discordant grading is frequent with aortic stenosis (AS) and preserved LVEF. Our study shows that in patients with low-flow, those with high-gradient had worse outcome than those with low-gradient, underscoring the need for early intervention (i.e., before gradient reaches 40 mmHg). Sex-differences have been observed in valve and myocardium in AS, but the guidelines' threshold defining low-flow is the same for men and women (35 ml/m2). The use of sex-specific thresholds for defining low-flow (32 ml/m2 for women and 40 ml/m2 for men) predicts mortality in both sexes and enhances risk stratification, outperforming the guidelines threshold of 35 ml/m2.
Competitiondate
201909
Approvedterm2
1 yr 0 mth
Pinamesdelim
Guzzetti, Ezequiel
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $1,000~ $0~
