Grant: Operating Grant: 17th JPIAMR transnational call for research projects (2024)
Queen's University (Kingston, Ontario)
$500,000.00
SHIELDing life: enhancing trained immunity against fungal threats
FY 2024-25
Summary
Fungal infections are a major health problem worldwide, hitting hardest those with weakened immune systems, such as cancer patients undergoing chemotherapy. Every year, these infections are responsible for over a million deaths globally. A growing concern is that many fungi are becoming resistant to existing drugs, making infections harder to treat.
Our research explores an exciting concept known as "trained immunity". This approach aims to boost the body's natural defenses, enabling it to fight off fungal infections more effectively, including those resistant to current treatments. Imagine giving your immune system a training program that makes it stronger and more prepared to defend against these dangerous fungi.
The goal of our project is to unlock new ways to treat fungal infections. By harnessing the power of trained immunity, we hope to provide a beacon of hope for those at high risk of these infections, particularly individuals undergoing chemotherapy. This research has the potential to revolutionize how we combat fungal diseases, offering new strategies to protect vulnerable populations and tackle the challenge of drug-resistant fungi.
Department
Program
Operating Grant: 17th JPIAMR transnational call for research projects (2024)
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
507130
Name
Kaufmann Eva
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Deutsches Zentrum fur Luft- und Raumfahrt (Germany); National Health and Medical Research Council of Australia; The Netherlands Organization for Health Research and Development (ZonMw)
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Special Cases
Projecttitle
SHIELDing life: enhancing trained immunity against fungal threats
Programtype2
Operating Grants
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$500,000
Cihrequipment2
$0
Programname2
Operating Grant: 17th JPIAMR transnational call for research projects (2024)
Keyworddelim
Cell-Based Therapy; Fungal Infections; Immunology; Immunosuppression; Innate Immune Memory; Trained Immunity
Abstract
Fungal infections are a major health problem worldwide, hitting hardest those with weakened immune systems, such as cancer patients undergoing chemotherapy. Every year, these infections are responsible for over a million deaths globally. A growing concern is that many fungi are becoming resistant to existing drugs, making infections harder to treat.
Our research explores an exciting concept known as "trained immunity". This approach aims to boost the body's natural defenses, enabling it to fight off fungal infections more effectively, including those resistant to current treatments. Imagine giving your immune system a training program that makes it stronger and more prepared to defend against these dangerous fungi.
The goal of our project is to unlock new ways to treat fungal infections. By harnessing the power of trained immunity, we hope to provide a beacon of hope for those at high risk of these infections, particularly individuals undergoing chemotherapy. This research has the potential to revolutionize how we combat fungal diseases, offering new strategies to protect vulnerable populations and tackle the challenge of drug-resistant fungi.
Competitiondate
202407
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Kaufmann, Eva
Approvedterm
3 ans 0 mois
Cihrcontribution2
MI #3~ $500,000~ $0~
