Grant: Operating Grant
Université de Montréal
$497,805.00
MHC II antigen presentation: Modulation by E3-ubiquitin ligases of the MARCH family
FY 2008-09
Summary
The immune system protects humans against pathogens and inflammation (redness, heat, swelling...) is part of the healing process. However, the body must put an end to these reactions in order to prevent complications and even auto-immune diseases. We have identified a molecule (MARCH1) that acts as a brake in the presence of anti-inflammatory messages such as the cytokine IL-10. MARCH1 acts by modifying the structure of other proteins through the addition of a ubiquitin tag. Our goal is to understand the regulation of MARCH1 in immune cells, identify its molecular targets and to characterize its structure and function. These results will help understanding inflammation, autoimmunity and possibly control organ transplantation.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
172135
Name
Thibodeau Jacques
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
MHC II antigen presentation: Modulation by E3-ubiquitin ligases of the MARCH family
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$497,805
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Antigen Presentation; Cytokines; Dendritic Cells; E3 Ubiquitin Ligase; Mhc Class Ii; Monocytes
Abstract
The immune system protects humans against pathogens and inflammation (redness, heat, swelling...) is part of the healing process. However, the body must put an end to these reactions in order to prevent complications and even auto-immune diseases. We have identified a molecule (MARCH1) that acts as a brake in the presence of anti-inflammatory messages such as the cytokine IL-10. MARCH1 acts by modifying the structure of other proteins through the addition of a ubiquitin tag. Our goal is to understand the regulation of MARCH1 in immune cells, identify its molecular targets and to characterize its structure and function. These results will help understanding inflammation, autoimmunity and possibly control organ transplantation.
Competitiondate
200809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Thibodeau, Jacques
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $497,805~ $0~
