Grant: Alliance Grants
Université d'Ottawa
$124,227.00
Bioprinting of eggshell membrane-based biomaterials for promotion of wound healing
FY 2024-25
Summary
The overall goal of this project is to develop a 3D bioprinted eggshell membrane (ESM)-based biomaterial for improved wound healing. Three-dimensional (3D) printing technology using bio-inks for layer-by-layer deposition can generate complex 3D-shaped materials, which has great potential for wound repair and regeneration since it can be customized as a bionic skin substitute to meet clinical/industrial requirements. 3D bioprinting is capable of high resolution, flexibility, reproducibility, and elevated throughput, to produce novel biomaterials with great potential for skin healing applications. Chronic, non-healing skin wounds are a challenging health problem worldwide and are associated with significant morbidity and mortality. In developed countries, about 1.5% of the population have complicated wounds, which account for 4% of all healthcare expenses. In the USA, chronic wounds affect 5-7 million patients yearly. The global active wound care market was valued at $1.4 Bn in 2017 and is projected to reach $2 bn in 2025. Worldwide, over 1.5 trillion table eggs are produced annually. About 30% of these are diverted to breaking plants, with generation of large quantities of undervalued eggshell (ES) and ESM waste. Recently we produced novel ESM particles with size-dependent antimicrobial and anti-inflammatory bioactivities via an innovative eco-friendly process, which have great potential as a novel bioink. ESM consists mainly of proteins, including those with structural (i.e. collagens), anti-inflammatory and antimicrobial properties. Alginate, cellulose, and chitosan are cost-effective, non-toxic, biocompatible, and biodegradable biopolymers, which are and easily manipulated; they will be combined with ESM particles to create novel engineered biomaterials for synergistic healing impact. This project is supported by Egg Farmers of Canada and Burnbrae Farms, one of Canada's most prominent egg producer. By expanding the biomedical market for ESM, we will enhance the competitiveness of the Canadian egg sector and contribute to a circular economy.
Program
Alliance Grants
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
592426-2023
Name nom
Hincke, Max MTC
Department département
Cellular and Molecular Medicine
Organization id
28
Institution établissement
Université d'Ottawa
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2024
Competition year année de concours
2023
Award amount
124227
Program id
ALLRP
Program name en
Alliance Grants
Program name fr
Subventions Alliance
Group en
RESEARCH PARTNERSHIPS
Group fr
PARTENARIATS DE RECHERCHE
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
1208
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Materials sciences
Area of application fr
Sciences des matériaux
Research subject code
1902
Research subject group en
Biomedical engineering
Research subject group fr
Génie biomédical
Research subject en
Biomedical materials
Research subject fr
Matériaux biomédicaux
Field of research list names en
Not available
Field of research list names fr
Non disponible
Socioeconomic objective list names en
Not available
Socioeconomic objective list names fr
Non disponible
Application title
Bioprinting of eggshell membrane-based biomaterials for promotion of wound healing
Keywords
biomaterial; bioprinting; eggshell membrane; skin; wound healing
Application summary
The overall goal of this project is to develop a 3D bioprinted eggshell membrane (ESM)-based biomaterial for improved wound healing. Three-dimensional (3D) printing technology using bio-inks for layer-by-layer deposition can generate complex 3D-shaped materials, which has great potential for wound repair and regeneration since it can be customized as a bionic skin substitute to meet clinical/industrial requirements. 3D bioprinting is capable of high resolution, flexibility, reproducibility, and elevated throughput, to produce novel biomaterials with great potential for skin healing applications. Chronic, non-healing skin wounds are a challenging health problem worldwide and are associated with significant morbidity and mortality. In developed countries, about 1.5% of the population have complicated wounds, which account for 4% of all healthcare expenses. In the USA, chronic wounds affect 5-7 million patients yearly. The global active wound care market was valued at $1.4 Bn in 2017 and is projected to reach $2 bn in 2025. Worldwide, over 1.5 trillion table eggs are produced annually. About 30% of these are diverted to breaking plants, with generation of large quantities of undervalued eggshell (ES) and ESM waste. Recently we produced novel ESM particles with size-dependent antimicrobial and anti-inflammatory bioactivities via an innovative eco-friendly process, which have great potential as a novel bioink. ESM consists mainly of proteins, including those with structural (i.e. collagens), anti-inflammatory and antimicrobial properties. Alginate, cellulose, and chitosan are cost-effective, non-toxic, biocompatible, and biodegradable biopolymers, which are and easily manipulated; they will be combined with ESM particles to create novel engineered biomaterials for synergistic healing impact. This project is supported by Egg Farmers of Canada and Burnbrae Farms, one of Canada's most prominent egg producer. By expanding the biomedical market for ESM, we will enhance the competitiveness of the Canadian egg sector and contribute to a circular economy.
