Grant: CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
University of Toronto
$3,000.00
An analysis of CCL2-secreting cells in the small intestine of Lymphotoxin-deficient mice
FY 2008-09
Summary
Inflammatory Bowel Disease affects nearly 200,000 Canadians. Currently, limited options
are available to treat patients with this disease. These include immunosuppression and
Tumour Necrosis Factor (TNF) blockers. However, not all patients are responsive to these
therapies. Our lab studies a receptor that is related to the TNF receptor called
Lymphotoxin-beta Receptor. Signals through this receptor help to organize white blood
cells within specialized organs called lymph nodes. The Lymphotoxin pathway also seems
to be important for certain organized lymphoid compartments in the gut as well. Our lab
is interested in how this pathway may provide signals within the gut that provoke the
accumulation of white blood cells in this environment. While this is likely important to
maintain the right balance of pro-inflammatory and anti-inflammatory signals in the gut,
if this balance is altered, inappropriate inflammation may occur leading to disease.
Department
Program
CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
182310
Name
Yu Dennis
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Canadian Association of Gastroenterology (Oakville, Ontario); Crohn's and Colitis Canada (Toronto, Ontario)
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
CIHR - INMD - CAG (Canadian Association of Gastroenterology) Partnership
Projecttitle
An analysis of CCL2-secreting cells in the small intestine of Lymphotoxin-deficient mice
Programtype2
Summer Student Programs
Orgnameinp2
University of Toronto
Cihramount2
$3,000
Cihrequipment2
$0
Programname2
CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
Keyworddelim
Chemokines; Inflammatory Bowel Disease; Lamina Propia; Lymphocytes; Small Intestine; Stomal Cells; Tnf Family Members
Abstract
Inflammatory Bowel Disease affects nearly 200,000 Canadians. Currently, limited options
are available to treat patients with this disease. These include immunosuppression and
Tumour Necrosis Factor (TNF) blockers. However, not all patients are responsive to these
therapies. Our lab studies a receptor that is related to the TNF receptor called
Lymphotoxin-beta Receptor. Signals through this receptor help to organize white blood
cells within specialized organs called lymph nodes. The Lymphotoxin pathway also seems
to be important for certain organized lymphoid compartments in the gut as well. Our lab
is interested in how this pathway may provide signals within the gut that provoke the
accumulation of white blood cells in this environment. While this is likely important to
maintain the right balance of pro-inflammatory and anti-inflammatory signals in the gut,
if this balance is altered, inappropriate inflammation may occur leading to disease.
Competitiondate
200902
Approvedterm2
0 yr 4 mths
Pinamesdelim
Yu, Dennis
Approvedterm
0 an 4 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $3,000~ $0~
