Grant: Project Grant
Université de Montréal
$757,350.00
Regulation of innate antiviral defenses through Interleukin-17 receptor D (IL-17RD)
FY 2020-21
Summary
The biological reasons why cells cannot innately defend themselves against viral infection are still not understood today. A good example of this observation can be seen in the present pandemic where some people defend themselves well while others are severely affected. Our preliminary data lead us to believe that we have identified a receptor type protein called "Interleukin 17 receptor; IL-17RD", which would oppose the activation of biochemical pathways allowing the production of cytokines with antiviral activity, type I and III interferons. By using cellular, molecular, and animal techniques, this research program thus aims to verify and understand the biological importance of the IL-17RD receptor in the innate antiviral response.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
433669
Name
Servant Marc
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis 2
Projecttitle
Regulation of innate antiviral defenses through Interleukin-17 receptor D (IL-17RD)
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$757,350
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Fine-Tuning Of The Antiviral Innate Immune Response; Ikk Complex; Il-17rd; Interferon Regulatory Factors (Irf) Transcription Factors; Nf-Kb Transcription Factor; Repressor Functions; Rig-I-Like Receptors; Rna Viruses; Tbk1; Type I/Iii Interferons
Abstract
The biological reasons why cells cannot innately defend themselves against viral infection are still not understood today. A good example of this observation can be seen in the present pandemic where some people defend themselves well while others are severely affected. Our preliminary data lead us to believe that we have identified a receptor type protein called "Interleukin 17 receptor; IL-17RD", which would oppose the activation of biochemical pathways allowing the production of cytokines with antiviral activity, type I and III interferons. By using cellular, molecular, and animal techniques, this research program thus aims to verify and understand the biological importance of the IL-17RD receptor in the innate antiviral response.
Competitiondate
202010
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Servant, Marc
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $757,350~ $0~
