Grant: Project Grant

Hypertension, or high blood pressure, affects >1 billion people in the World and is a major risk factor for several vascular diseases, including stroke, heart attack and heart failure. Endothelial cells, which form the inner layer of blood vessels, actively module the vascular tone by secreting vasoactive molecules. In this project, we will use human genetic and functional genomic approaches to identify the genes that control how endothelial cells influence blood pressure in humans. This project will lead to a better understanding of the mechanisms that lead to hypertension, and might guide to the development of better therapies.