Grant: Operating Grant
McMaster University
$388,746.00
Mechanisms by which Diabetes Mellitus promotes the development and progression of atherosclerosis
FY 2008-09
Summary
Over 75% of people with diabetes will die prematurely of heart attack or stroke. The goal of our research is to; i) determine why, and ii) to find ways to prevent this from happening. We have identified a novel pathway within the cells of the body. This pathway is activated by high levels of sugar in the blood (hyperglycemia) and can result in damage to the cells of the blood vessel walls. We are currently testing the importance of this pathway and identifying specific points within the pathway that we can target with drugs to block disease progression. These studies are important because our increased understanding of these disease processes will permit a rational approach to the development of treatments and prevention strategies.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
170868
Name
Werstuck Geoffrey H
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Metabolism
Projecttitle
Mechanisms by which Diabetes Mellitus promotes the development and progression of atherosclerosis
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$388,746
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Atherosclerosis; Diabetes Mellitus; Endoplasmic Reticulum Stress; Glutamine:Fructose-6 Phosphate Amidotransferase; Mouse Models
Abstract
Over 75% of people with diabetes will die prematurely of heart attack or stroke. The goal of our research is to; i) determine why, and ii) to find ways to prevent this from happening. We have identified a novel pathway within the cells of the body. This pathway is activated by high levels of sugar in the blood (hyperglycemia) and can result in damage to the cells of the blood vessel walls. We are currently testing the importance of this pathway and identifying specific points within the pathway that we can target with drugs to block disease progression. These studies are important because our increased understanding of these disease processes will permit a rational approach to the development of treatments and prevention strategies.
Competitiondate
200809
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Werstuck, Geoffrey H
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $388,746~ $0~
