Grant: Project Grant
Université Laval
$715,276.00
Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology
FY 2017-18
Summary
The ultimate goal of this research proposal is to develop a novel therapeutical approach to treat patients suffering from muscular dystrophy (MD). Our recent observations suggest that a
treatment, which increases the biosynthesis of galectin-3 ligands, improves maximum force strength of the muscle of Duchenne muscular dystrophy (DMD) in vivo and myogenesis of muscle cells derived from normal mice in vitro. Based on this novel observation, the overall goal of this proposal is to develop a novel approach for MD therapy using a conventional chemical compound that can increase the biosynthesis of galectin-3 ligands. To this end, the
aim of this proposal is to investigate the underlying molecular mechanism by which galectin-3 improves muscle regeneration and mitigate the progression of MD.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
380420
Name
Sato Sachiko
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Movement & Exercise
Projecttitle
Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$715,276
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Galectins; Glycobiology; Muscular Dystrophy; Myogenesis; Treatment
Abstract
The ultimate goal of this research proposal is to develop a novel therapeutical approach to treat patients suffering from muscular dystrophy (MD). Our recent observations suggest that a
treatment, which increases the biosynthesis of galectin-3 ligands, improves maximum force strength of the muscle of Duchenne muscular dystrophy (DMD) in vivo and myogenesis of muscle cells derived from normal mice in vitro. Based on this novel observation, the overall goal of this proposal is to develop a novel approach for MD therapy using a conventional chemical compound that can increase the biosynthesis of galectin-3 ligands. To this end, the
aim of this proposal is to investigate the underlying molecular mechanism by which galectin-3 improves muscle regeneration and mitigate the progression of MD.
Competitiondate
201803
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sato, Sachiko
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $715,276~ $0~
