Grant: Canada Research Chairs
Université d'Ottawa
$200,000.00
Genomics and the Environment
FY 2024-25
Summary
This research program addresses an urgent need to modernize human health risk assessment of environmental chemicals to increase efficiency, reduce cost, and reduce the large numbers of animals required for toxicological testing. The main objective is to develop and deploy approaches that quantify how toxic chemicals can modulate the function of genes or damage genetic material (ie, genomics), and use this information to predict toxicological effects in humans. The program bridges basic and applied sciences, bringing together the research and regulatory communities in academia and government to advance regulatory processes and decision-making.
Program
Canada Research Chairs
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
CRC-2020-00060
Name nom
Yauk, Carole
Department département
Biology - University of Ottawa
Organization id
28
Institution établissement
Université d'Ottawa
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2024
Competition year année de concours
2020
Award amount
200000
Program id
CRC
Program name en
Canada Research Chairs
Program name fr
Chaires de recherche du Canada
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
9998
Committee name en
Canada Research Chair Selection Committee
Committee name fr
Comité de sélection des Chaires de recherche du Canada
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
9999
Research subject group en
Not available
Research subject group fr
Non disponible
Research subject en
Not available
Research subject fr
Non disponible
Field of research list codes
RDF10605; RDF30302
Field of research list names en
Biological evolution;Public and population health
Field of research list names fr
Biologie de l'évolution;Santé publique et santé des populations
Socioeconomic objective list names en
Not available
Socioeconomic objective list names fr
Non disponible
Application title
Genomics and the Environment
Keywords
toxicogenomics; genetic toxicology; genomics; genetics; mutation; mutagenesis; toxicology; risk assessment; regulatory toxicology; next-generation sequencing; germ cell mutation; public health; dose-response analysis; benchmark dose; adverse outcome pathway; mechanistic toxicology; new approach methodologies; high-throughput screening; transcriptomics
Application summary
This research program addresses an urgent need to modernize human health risk assessment of environmental chemicals to increase efficiency, reduce cost, and reduce the large numbers of animals required for toxicological testing. The main objective is to develop and deploy approaches that quantify how toxic chemicals can modulate the function of genes or damage genetic material (ie, genomics), and use this information to predict toxicological effects in humans. The program bridges basic and applied sciences, bringing together the research and regulatory communities in academia and government to advance regulatory processes and decision-making.
