Grant: Operating Grant
Unity Health Toronto
$806,879.00
Mechanisms of human neutrophil peptides in lung inflammation
FY 2010-11
Summary
Acute lung injury is known to be related to white blood cell invasion into the lung. However, how exactly the white blood cells cause lung injury remains unclear. We found that the proteins named human neutrophil peptides (HNP) released from white blood cells during infection can induce lung injury. The present research proposal will identify the proteins that can recognize HNP by lung cells so that we will design medications to block those proteins interacting with HNP thus reduce and prevent lung injury.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
223460
Name
Zhang Haibo
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
Mechanisms of human neutrophil peptides in lung inflammation
Programtype2
Operating Grants
Orgnameinp2
Unity Health Toronto
Cihramount2
$806,879
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Acute Lung Injury; Ards
Abstract
Acute lung injury is known to be related to white blood cell invasion into the lung. However, how exactly the white blood cells cause lung injury remains unclear. We found that the proteins named human neutrophil peptides (HNP) released from white blood cells during infection can induce lung injury. The present research proposal will identify the proteins that can recognize HNP by lung cells so that we will design medications to block those proteins interacting with HNP thus reduce and prevent lung injury.
Competitiondate
201103
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Zhang, Haibo
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $806,879~ $0~
