Grant: Project Grant
University of British Columbia
$822,375.00
The BCC3 cohort: Cellular aging in women living with HIV
FY 2018-19
Summary
People living with HIV show accelerated aging meaning they experience age-related illnesses earlier in life. This is clearly related to their HIV infection, but it could also be exacerbated by the treatment they receive, as well as by other viral infections of the type that stay with people for life (i.e. herpes virus and chicken pox virus)., or even bad habits such as smoking. Smoking rates are high among people living with HIV in Canada. This research will try to elucidate the contribution of each of these factors to the aging of immune cells, and how this may relate to age-associated illnesses and conditions such as cardiovascular disease, liver disease and cancer. We will study women living with HIV or not whom we have already been following for a long time. We will measure markers of aging, and consider other factors such as life habits, psychosocial stressors such as stigma or raciism, to understand what drives the acceleration of natural aging.
Department
Program
Project Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
389315
Name
Côté Hélène
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Biological and Clinical Aspects of Aging
Projecttitle
The BCC3 cohort: Cellular aging in women living with HIV
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$822,375
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Antiretroviral Therapy; Comorbidities; Hiv; Immune Senescence; Mental Health; Mitochondrial Aging; Stbbi; Telomere Length
Abstract
People living with HIV show accelerated aging meaning they experience age-related illnesses earlier in life. This is clearly related to their HIV infection, but it could also be exacerbated by the treatment they receive, as well as by other viral infections of the type that stay with people for life (i.e. herpes virus and chicken pox virus)., or even bad habits such as smoking. Smoking rates are high among people living with HIV in Canada. This research will try to elucidate the contribution of each of these factors to the aging of immune cells, and how this may relate to age-associated illnesses and conditions such as cardiovascular disease, liver disease and cancer. We will study women living with HIV or not whom we have already been following for a long time. We will measure markers of aging, and consider other factors such as life habits, psychosocial stressors such as stigma or raciism, to understand what drives the acceleration of natural aging.
Competitiondate
201809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Côté, Hélène
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $822,375~ $0~
