Grant: Catalyst Grant: Pandemic Outbreak Research Response
Centre hospitalier de l'Université de Montréal (CHUM)
$297,105.00
Controlling the Influenza A H1N1 pandemic strain infection: dynamics and mechanisms of innate and adaptive immune responses in a system biology approach
FY 2009-10
Summary
Influenza AH1N1 has spread all over the world. The clinical manifestations of the disease vary from one individual to another, some having a very severe form of disease leading to death while others have a milder form of disease. Little is known about the risk factors and the host genetics that may lead to these differences in the course of infection. We propose to study a well powered cohort of subjects infected with influenza AH1N1 and evaluate their immune responses and other factors that may contribute to the different courses observed in the natural history of this infection ; we will use a system biology approach that includes comprehensive immunological and virological approach with the aim of defining if the innate immune response induced by the virus influences the adaptive immune response . This will help us design immune based preventive and therapeutic strategies for those individuals at higher risk of severe illness.
Department
Program
Catalyst Grant: Pandemic Outbreak Research Response
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
189107
Name
Tremblay Cécile L
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Catalyst Grant: Pandemic Outbreak Research Response
Projecttitle
Controlling the Influenza A H1N1 pandemic strain infection: dynamics and mechanisms of innate and adaptive immune responses in a system biology approach
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$297,105
Cihrequipment2
$0
Programname2
Catalyst Grant: Pandemic Outbreak Research Response
Keyworddelim
Host Genetics; Immunological Responses; Influenza A H1n1; Viral Expression; Viremia; Virulence
Abstract
Influenza AH1N1 has spread all over the world. The clinical manifestations of the disease vary from one individual to another, some having a very severe form of disease leading to death while others have a milder form of disease. Little is known about the risk factors and the host genetics that may lead to these differences in the course of infection. We propose to study a well powered cohort of subjects infected with influenza AH1N1 and evaluate their immune responses and other factors that may contribute to the different courses observed in the natural history of this infection ; we will use a system biology approach that includes comprehensive immunological and virological approach with the aim of defining if the innate immune response induced by the virus influences the adaptive immune response . This will help us design immune based preventive and therapeutic strategies for those individuals at higher risk of severe illness.
Competitiondate
200908
Approvedterm2
1 yr 0 mth
Pinamesdelim
Tremblay, Cécile L; Sekaly, Rafick-Pierre; Trautmann, Lydie
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $297,105~ $0~
