Grant: CIHR-ICRH Travel Awards - General pool
McGill University
$1,500.00
Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats
FY 2022-23
Summary
Although there is a known mutually antagonistic nature of TH1 and TH2 immune responses, the role of the former in asthma pathogenesis is unclear. We adopted an ovalbumin (OVA)-induced Brown-Norway (BN) rat “asthma” model with the co-administration of polyinosinic:polycytidylic acid (PIC), which is a mimic of viral double-stranded RNA that initiates interferon responses. Hypothesis and aims: We hypothesized that the co-administration of PIC during intrapulmonary allergen challenges results in elevated TH1 immunopathology, which corresponds to a distinct disease phenotype. We aimed to investigate the effect of PIC co-administration on airway hyperresponsiveness (AHR), inflammation and remodelling, and to elucidate the impact of PIC-induced TH1 immunopathology on TH2 immunity and vice versa in the rat allergic asthma model.
Department
Program
CIHR-ICRH Travel Awards - General pool
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
480732
Name
Sun Rui
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Prcname2
Special Cases
Projecttitle
Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats
Programtype2
Undefined
Orgnameinp2
McGill University
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
CIHR-ICRH Travel Awards - General pool
Keyworddelim
Airway Inflammation; Allergy; Asthma; Sensitized Rats; Synthetic Double-Stranded Rna
Abstract
Although there is a known mutually antagonistic nature of TH1 and TH2 immune responses, the role of the former in asthma pathogenesis is unclear. We adopted an ovalbumin (OVA)-induced Brown-Norway (BN) rat “asthma” model with the co-administration of polyinosinic:polycytidylic acid (PIC), which is a mimic of viral double-stranded RNA that initiates interferon responses. Hypothesis and aims: We hypothesized that the co-administration of PIC during intrapulmonary allergen challenges results in elevated TH1 immunopathology, which corresponds to a distinct disease phenotype. We aimed to investigate the effect of PIC co-administration on airway hyperresponsiveness (AHR), inflammation and remodelling, and to elucidate the impact of PIC-induced TH1 immunopathology on TH2 immunity and vice versa in the rat allergic asthma model.
Competitiondate
202301
Approvedterm2
1 yr 0 mth
Pinamesdelim
Sun, Rui
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $1,500~ $0~
