Grant: Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
University of British Columbia
$70,000.00
Coordinating functions of SWR1 and NuA4 complexes in histone variant H2A.Z deposition and histone acetylation
FY 2008-09
Summary
Chromatin is a complex and compact structure made up of DNA wrapped around histone proteins. Failure to maintain chromatin integrity can lead to the development of several human diseases. Many different protein complexes can alter chromatin structure. My research focuses on the Tip60 complex, a chromatin-modifying complex which has a role in HIV biology and which can act as a tumor suppressor. In yeast, Tip60 is found as two separate complexes: the NuA4 and SWR1 complexes which affect chromatin structure by modifying histone proteins in two different ways. The different histone modifications have several disctinct functions associated with DNA processes such as repair, replication and transcription. I am investigating the functional relationship existing between the SWR1 and NuA4 complexes which have each different functions but share common interacting partners. Elucidating the function of these partners will lead to a better understanding of the role these complexes play in chromatin biology and will ultimately contribute to the development of therapies for diseases such as HIV and cancer.
Department
Program
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
184654
Name
Lévesque Nancy
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Doctoral Research Awards - A
Projecttitle
Coordinating functions of SWR1 and NuA4 complexes in histone variant H2A.Z deposition and histone acetylation
Programtype2
Studentship Programs
Orgnameinp2
University of British Columbia
Cihramount2
$70,000
Cihrequipment2
$0
Programname2
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Keyworddelim
Chromatin Biology; Complex Purification; Epigenetics; Genetic Interactions; Genome Integrity; Histone Acetyl Transferase; Histone Modifications; Protein Complexes; Protein-Protein Interactions; Yeast Genetics
Abstract
Chromatin is a complex and compact structure made up of DNA wrapped around histone proteins. Failure to maintain chromatin integrity can lead to the development of several human diseases. Many different protein complexes can alter chromatin structure. My research focuses on the Tip60 complex, a chromatin-modifying complex which has a role in HIV biology and which can act as a tumor suppressor. In yeast, Tip60 is found as two separate complexes: the NuA4 and SWR1 complexes which affect chromatin structure by modifying histone proteins in two different ways. The different histone modifications have several disctinct functions associated with DNA processes such as repair, replication and transcription. I am investigating the functional relationship existing between the SWR1 and NuA4 complexes which have each different functions but share common interacting partners. Elucidating the function of these partners will lead to a better understanding of the role these complexes play in chromatin biology and will ultimately contribute to the development of therapies for diseases such as HIV and cancer.
Competitiondate
200810
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Lévesque, Nancy
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $70,000~ $0~
