Grant: Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Centre hospitalier de l'Université de Montréal (CHUM)
$375,000.00
CD4 T cell plasticity and residual immune dysregulation syndrome in the new ART era
FY 2013-14
Summary
Antiviral therapy (ART) that blocks replication of HIV has resulted in a dramatic improvement in the quality of life for people living with HIV/AIDS. Specific white cells called CD4 T cells that recognize microbes and viruses and act as coordinators of the immune system are a major target of HIV. They fail to fully recover in a significant proportion of HIV-infected people in spite of anti-HIV treatment. As a consequence, these persons are still suffering from chronic inflammation and long-term complications of HIV infection. In these studies, we propose to identify mechanisms that prevent proper restoration of CD4 T cell responses in these infected persons, and to identify mechanisms that could be targeted to improve their recovery.
Department
Program
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
310126
Name
Kaufmann Daniel E
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Public Health Agency of Canada
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
CD4 T cell plasticity and residual immune dysregulation syndrome in the new ART era
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$375,000
Cihrequipment2
$0
Programname2
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Keyworddelim
Art; Cd4 T Cell; Cd4 T Cell Plasticity; Chronic Inflammation; Gut-Associated Lymphoid Tissue; Hiv; Immune Dysfunction; Immune Restoration
Abstract
Antiviral therapy (ART) that blocks replication of HIV has resulted in a dramatic improvement in the quality of life for people living with HIV/AIDS. Specific white cells called CD4 T cells that recognize microbes and viruses and act as coordinators of the immune system are a major target of HIV. They fail to fully recover in a significant proportion of HIV-infected people in spite of anti-HIV treatment. As a consequence, these persons are still suffering from chronic inflammation and long-term complications of HIV infection. In these studies, we propose to identify mechanisms that prevent proper restoration of CD4 T cell responses in these infected persons, and to identify mechanisms that could be targeted to improve their recovery.
Competitiondate
201403
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Kaufmann, Daniel E
Approvedterm
3 ans 0 mois
Cihrcontribution2
HIV/AIDS~ $375,000~ $0~
