Grant: Project Grant
University of Alberta
$837,675.00
Structure-function relationships at DNA double-strand break repair centers
FY 2018-19
Summary
When our genome is damaged, the cell has the potential to gain or lose genetic information and this can destabilize the cell, potentially leading to cell death or cancer. To repair the damaged DNA, the cell assembles distinct sites where the various factors that act on the DNA are concentrated. There is evidence that how these proteins are organized within these sites is important to the efficient repair of this DNA damage and preserving the fidelity of the
genome. We want to apply new developed electron microscopy technology to study this organization and its relationship to the repair of the DNA by directly capturing pictures of this site and the protein and DNA components that comprise it while they are undertaking the process of repairing our DNA.
Department
Program
Project Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
389213
Name
Hendzel Michael J
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Structure-function relationships at DNA double-strand break repair centers
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$837,675
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
53bp1; Brca1; Chromatin; Dna Double-Strand Break Repair; Dna End Resection; Electron Microscopy; Histone; Homologous Recombination; Ir-Induced Foci; Nonhomologous End Joining
Abstract
When our genome is damaged, the cell has the potential to gain or lose genetic information and this can destabilize the cell, potentially leading to cell death or cancer. To repair the damaged DNA, the cell assembles distinct sites where the various factors that act on the DNA are concentrated. There is evidence that how these proteins are organized within these sites is important to the efficient repair of this DNA damage and preserving the fidelity of the
genome. We want to apply new developed electron microscopy technology to study this organization and its relationship to the repair of the DNA by directly capturing pictures of this site and the protein and DNA components that comprise it while they are undertaking the process of repairing our DNA.
Competitiondate
201809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Hendzel, Michael J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $837,675~ $0~
