Grant: Collaborative Health Research Projects (NSERC partnered)
McMaster University
$338,199.00
Overcoming Antibiotic Resistance Through the Inhibition of Aminoglycoside Phosphotransferases (APH).
FY 2012-13
Summary
Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on the Canadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible for conferring resistance to the antibiotic. We have recently discovered a family of compounds that blocks the action of a series of aminoglycoside phosphotransferases (APH) and wish to develop the compounds to ultimately provide an optimized, on- target, on-mechanism lead suitable for development into a therapeutic agent.
Department
Program
Collaborative Health Research Projects (NSERC partnered)
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
269774
Name
Capretta Alfredo A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Natural Sciences and Engineering Research Council of Canada (NSERC)
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Collaborative Health Research Projects - NSERC Partnered
Projecttitle
Overcoming Antibiotic Resistance Through the Inhibition of Aminoglycoside Phosphotransferases (APH).
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$338,199
Cihrequipment2
$0
Programname2
Collaborative Health Research Projects (NSERC partnered)
Keyworddelim
Aminoglycoside Phosphotransferases; Antibiotic Resistance; Enzymes (5404); Human Health (1101); Medical And Health Sciences (1211); Medicinal Chemistry; Organic Syntheses (3703); Rational Based Drug Design; Structural Biology; X-Ray Crystallography
Abstract
Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on the Canadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible for conferring resistance to the antibiotic. We have recently discovered a family of compounds that blocks the action of a series of aminoglycoside phosphotransferases (APH) and wish to develop the compounds to ultimately provide an optimized, on- target, on-mechanism lead suitable for development into a therapeutic agent.
Competitiondate
201210
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Capretta, Alfredo A; Savchenko, Alexei; Wright, Gerard D
Approvedterm
3 ans 0 mois
Cihrcontribution2
Institute of Genetics~ $169,098~ $0~Knowledge Translation Branch~ $169,101~ $0~
