Grant: Project Grant

Mitochondria are the organelles responsible for energy (ATP) production in most cell types. As we age, there is evidence that mitochondrial function declines and that the concentration of mitochondria in muscle cells is reduced. This can result in poor energy production, fatigue and decreased quality of life. However, the reasons for the reduced mitochondrial concentration and function are not well known. In addition, evidence exists that exercise prevents this decrease, but the underlying mechanisms are not established. While considerable work has been devoted to studying the synthesis of mitochondria and how this could be affected with age, virtually nothing is known about the control of mitochondrial breakdown, termed mitophagy. The mitophagy pathway, including its terminal organelle the lysosome, and the effects of exercise, will be studied in the current proposal. This research is important for our understanding of how exercise can improve musculoskeletal health during the aging process, with important consequences for the well-being of Canadians.