Grant: Project Grant
University of Toronto
$952,425.00
Coronavirus Adaptation: Receptor Binding, Immune Evasion and Cross-Species Transmission
FY 2018-19
Summary
The human common cold is caused by one of several coronaviruses in 15-30% of all cases. Coronaviruses are also responsible for SARS and MERS, human respiratory diseases with a very high rate of fatality. By studying the S-protein of coronaviruses, we seek to determine the role it plays in the infection process, how it mediates escape from the human immune system, and how it enables transmission to humans from other species. In the long term, our studies are expected to be of value in the design of vaccines and therapeutics aimed at preventing and treating coronavirus infections.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
388870
Name
Rini James M
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - A
Projecttitle
Coronavirus Adaptation: Receptor Binding, Immune Evasion and Cross-Species Transmission
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$952,425
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cryo Electron Microscopy; Neutralizing Antibodies; Viral Glycoproteins; Viral Receptors; X-Ray Crystallography
Abstract
The human common cold is caused by one of several coronaviruses in 15-30% of all cases. Coronaviruses are also responsible for SARS and MERS, human respiratory diseases with a very high rate of fatality. By studying the S-protein of coronaviruses, we seek to determine the role it plays in the infection process, how it mediates escape from the human immune system, and how it enables transmission to humans from other species. In the long term, our studies are expected to be of value in the design of vaccines and therapeutics aimed at preventing and treating coronavirus infections.
Competitiondate
201809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Rini, James M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $952,425~ $0~
