Grant: Project Grant - PA: Nutrition, Metabolism and Diabetes
University of British Columbia
$100,000.00
Islet macrophages: regulators of beta cell function in health and diabetes
FY 2024-25
Summary
Macrophages are an immune cell known as the garbage eaters of the body because they "eat" up and remove dead and dying cells and debris. They also provide signals to other cells that are important in regeneration and growth, and are important in inflammation in disease. In the pancreas, macrophages are becoming appreciated for their role in regulating insulin production, and contributing to type 1 and type 2 diabetes. We aim to better understand how macrophages in the pancreas can play both supportive roles in cell growth and regeneration, and inflammatory roles in diabetes. We also aim to use nanomedicines to target pancreas macrophages for therapy in diabetes.
Department
Program
Project Grant - PA: Nutrition, Metabolism and Diabetes
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
515618
Name
Verchere Bruce C
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Islet macrophages: regulators of beta cell function in health and diabetes
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Project Grant - PA: Nutrition, Metabolism and Diabetes
Keyworddelim
Amyloid; Diabetes; Human Islets; Inflammation; Innate Immunity; Macrophages; Nanomedicines; Transcriptomics; Transgenic Mice; Type 2 Diabetes
Abstract
Macrophages are an immune cell known as the garbage eaters of the body because they "eat" up and remove dead and dying cells and debris. They also provide signals to other cells that are important in regeneration and growth, and are important in inflammation in disease. In the pancreas, macrophages are becoming appreciated for their role in regulating insulin production, and contributing to type 1 and type 2 diabetes. We aim to better understand how macrophages in the pancreas can play both supportive roles in cell growth and regeneration, and inflammatory roles in diabetes. We also aim to use nanomedicines to target pancreas macrophages for therapy in diabetes.
Competitiondate
202409
Approvedterm2
1 yr 0 mth
Pinamesdelim
Verchere, Bruce C
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
