Grant: Operating Grant
University of Alberta
$656,307.00
Role of SirT1 in the regulation of pancreatic beta-cell mass and function
FY 2012-13
Summary
Insulin is produced in the pancreas by specialized cells, named beta-cells. Type 1 diabetes results from selective destruction of beta-cells. Type 2 diabetes is characterized by both insulin resistance and a progressive deterioration of beta-cells. Therefore, diabetes treatment should aim at preserving and expanding surviving beta-cells.
In this project, we are going to study the role of a particular protein called SirT1 in the regulation of beta-cell survival and expansion. We will also try to understand how the activity of this protein is regulated. The ultimate goal of our research proposal is to characterize SirT1 as a target for diabetes treatment.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
279692
Name
Buteau Jean
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Role of SirT1 in the regulation of pancreatic beta-cell mass and function
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$656,307
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Animal Models; Apoptosis; Diabetes; Gene Expression; Insulin Secretion; Metabolism; Pancreatic Beta-Cells; Proliferation; Transcription Factors
Abstract
Insulin is produced in the pancreas by specialized cells, named beta-cells. Type 1 diabetes results from selective destruction of beta-cells. Type 2 diabetes is characterized by both insulin resistance and a progressive deterioration of beta-cells. Therefore, diabetes treatment should aim at preserving and expanding surviving beta-cells.
In this project, we are going to study the role of a particular protein called SirT1 in the regulation of beta-cell survival and expansion. We will also try to understand how the activity of this protein is regulated. The ultimate goal of our research proposal is to characterize SirT1 as a target for diabetes treatment.
Competitiondate
201303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Buteau, Jean
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $656,307~ $0~
