Grant: Project Grant
Unity Health Toronto
$857,565.00
Imaging of Transplant Kidney Fibrosis and Inflammation Using Quantitative and Nanobubble Enhanced Ultrasound
FY 2025-26
Summary
Affecting 1 in every 10 Canadians, kidney disease is a major public health problem. Kidney transplantation restores kidney function, and can greatly improve lifespan and quality of life. Unfortunately, transplant kidneys often become injured over time, with inflammation and scarring being two forms of damage that commonly occur.
Currently, the only way to measure transplant kidney inflammation and scarring is by a painful biopsy. Our team is developing a new bedside ultrasound technology that can "see" the scarring and inflammation in transplant kidneys using safe, easy-to-perform ultrasound scans. By adding special bubbles and advanced computer analysis, we can detect kidney damage early, track how it changes, and help doctors choose the best treatments-without the need for a biopsy. This breakthrough could make kidney care safer, more accurate, and more personalized for patients everywhere.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
533881
Name
Yuen Darren A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Clinical Investigation - C: Digestive, Endocrine and Excretory Systems
Projecttitle
Imaging of Transplant Kidney Fibrosis and Inflammation Using Quantitative and Nanobubble Enhanced Ultrasound
Programtype2
Operating Grants
Orgnameinp2
Unity Health Toronto
Cihramount2
$857,565
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Fibrosis; Inflammation; Kidney; Machine Learning; Nanobubbles; Ultrasound
Abstract
Affecting 1 in every 10 Canadians, kidney disease is a major public health problem. Kidney transplantation restores kidney function, and can greatly improve lifespan and quality of life. Unfortunately, transplant kidneys often become injured over time, with inflammation and scarring being two forms of damage that commonly occur.
Currently, the only way to measure transplant kidney inflammation and scarring is by a painful biopsy. Our team is developing a new bedside ultrasound technology that can "see" the scarring and inflammation in transplant kidneys using safe, easy-to-perform ultrasound scans. By adding special bubbles and advanced computer analysis, we can detect kidney damage early, track how it changes, and help doctors choose the best treatments-without the need for a biopsy. This breakthrough could make kidney care safer, more accurate, and more personalized for patients everywhere.
Competitiondate
202509
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Yuen, Darren A; Hysi, Eno; Kolios, Michael C
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $857,565~ $0~
