Grant: Operating Grant
Ottawa Hospital Research Institute
$394,050.00
Tranexamic acid during cystectomy trial (TACT)
FY 2014-15
Summary
A cystectomy is the removal of the bladder and adjacent organs in patients with bladder cancer. This often results in significant blood loss, and about 60% of patients will require blood transfusion during surgery. Significant blood loss may result in cardiovascular morbidity, and the use of blood products are expensive and expose patients to risk. Tranexamic acid reduces breakdown of hemostatic blood clots and it has therapeutic benefit when used in other surgical procedures to reduce blood loss and the need for transfusion. The current study will be the first to evaluate whether tranexamic acid is effective and safe to use during radical cystectomy. The results of the study will have an immediate impact on patient care.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
322432
Name
Breau Rodney H
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Clinical Investigation - C: Digestive, Endocrine and Excretory Systems
Projecttitle
Tranexamic acid during cystectomy trial (TACT)
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$394,050
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Blood Conservation; Cystectomy; Randomized Controlled Trial; Systemic Antihemorrhagics; Tranexamic Acid
Abstract
A cystectomy is the removal of the bladder and adjacent organs in patients with bladder cancer. This often results in significant blood loss, and about 60% of patients will require blood transfusion during surgery. Significant blood loss may result in cardiovascular morbidity, and the use of blood products are expensive and expose patients to risk. Tranexamic acid reduces breakdown of hemostatic blood clots and it has therapeutic benefit when used in other surgical procedures to reduce blood loss and the need for transfusion. The current study will be the first to evaluate whether tranexamic acid is effective and safe to use during radical cystectomy. The results of the study will have an immediate impact on patient care.
Competitiondate
201503
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Breau, Rodney H; Cagiannos, Ilias; Momoli, Franco
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $394,050~ $0~
