Grant: Operating Grant
University of Manitoba
$388,829.00
Mechanisms and consequences of three-dimensional (3D) nuclear remodeling of telomeres in cancer
FY 2008-09
Summary
We have previously shown that the structural order of the cell is changed when cells become tumor cells. To document this, we have studied one central component in the cell that is called the nucleus. The nucleus contains our genetic information. The structural order of the nucleus is what differentiates a normal cell from a cancer cell. In other words, if the order of this structure is compromised, the cell is not normal anymore. We propose to identify mechanisms through which the structural organization of the nucleus can be changed. We will define the changes that are required for cells to become cancerous.
This study is highly relevant for our understanding of early changes that lead to cancer. In the future, we propose to use the defined changes for the screening of patients at risk of cancer, for monitoring of their disease progression and of treatment success.
Department
Program
Operating Grant
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
170666
Name
Mai Sabine
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Mechanisms and consequences of three-dimensional (3D) nuclear remodeling of telomeres in cancer
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$388,829
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
C-Myc; Genomic Instability; Spectral Karyotyping; Telomere And Interphase Nucleus; Three-Dimensional Imaging; Tumor Initiation
Abstract
We have previously shown that the structural order of the cell is changed when cells become tumor cells. To document this, we have studied one central component in the cell that is called the nucleus. The nucleus contains our genetic information. The structural order of the nucleus is what differentiates a normal cell from a cancer cell. In other words, if the order of this structure is compromised, the cell is not normal anymore. We propose to identify mechanisms through which the structural organization of the nucleus can be changed. We will define the changes that are required for cells to become cancerous.
This study is highly relevant for our understanding of early changes that lead to cancer. In the future, we propose to use the defined changes for the screening of patients at risk of cancer, for monitoring of their disease progression and of treatment success.
Competitiondate
200809
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Mai, Sabine
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $388,829~ $0~
