Grant: Project Grant

Doxorubicin is a very effective anti-cancer drug. Unfortunately, the administration of doxorubicin hurts several muscles including the heart by reducing their mass or by causing a weakening. Here, we propose to study how the cells that protect the body against infection participate in this process. We have seen that a type of defence cell called neutrophil infiltrates muscles after doxorubicin injection and, we believe, that they produce factors that induce the destruction of muscle mass.