Grant: Travel Awards - Institute Community Support
Direct Payment
$500.00
Microparticles induce Endothelial Cell Senescence and Cell Cycle Arrest through Redox-sensitive Processes: Implications in Vascular Aging
FY 2011-12
Summary
With aging, blood vessels change and become less effective. In diseases such as diabetes or kidney disease, blood vessels can age prematurely and this is termed "early vascular aging". However how these changes to the blood vessel happen is unknown.
This study examined how microparticles, tiny pieces of cells that are released from dying cells in the body, may cause blood vessels to age. We found that microparticles are released from aged cells and that these microparticles can cause cells of the blood vessel to age prematurely. We hope that understanding these processes may lead to treatments which can slow or prevent the age-related changes to blood vessels.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
252084
Name
Burger Dylan E
Region
Ontario
Country
Canada
Orgtype
Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Institute of Circulatory and Respiratory Health
Projecttitle
Microparticles induce Endothelial Cell Senescence and Cell Cycle Arrest through Redox-sensitive Processes: Implications in Vascular Aging
Programtype2
Undefined
Orgnameinp2
Direct Payment
Cihramount2
$500
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Aging; Cell Cycle; Endothelial Cells; Ics Travel Award; Microparticles; Oxidative Stress; Senescence; Vascular
Abstract
With aging, blood vessels change and become less effective. In diseases such as diabetes or kidney disease, blood vessels can age prematurely and this is termed "early vascular aging". However how these changes to the blood vessel happen is unknown.
This study examined how microparticles, tiny pieces of cells that are released from dying cells in the body, may cause blood vessels to age. We found that microparticles are released from aged cells and that these microparticles can cause cells of the blood vessel to age prematurely. We hope that understanding these processes may lead to treatments which can slow or prevent the age-related changes to blood vessels.
Competitiondate
201201
Approvedterm2
0 yr 1 mth
Pinamesdelim
Burger, Dylan E
Approvedterm
0 an 1 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $500~ $0~
