Grant: Discovery Grants Program - Individual
Concordia University
$44,250.00
the energetics of conformational interconversions plasminogen
FY 2008-09
Summary
We study the blood protein, plasminogen. It is the body's first line of defense against unwanted, internal blood clots. It is also involved in tissue remodeling such as occurs during lactation and tumour metastasis. Plasminogen binds to a clot or cell, opens and can then be activated to plasmin, the enzymatic form. On binding, the plasminogen undergoes a large conformational change; it is part of the activation process. Our long term goal is to be able to activate plasminogen at will when it is desirable, and inhibit its activation when it is undesirable. In order to do that we need a firm grasp of the factors that dictate which conformations are present, when they are present and what promotes or inhibits their interconversion.
Program
Discovery Grants Program - Individual
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
9988-2006
Name nom
Kornblatt, Jack
Department département
Biology
Organization id
70
Institution établissement
Concordia University
Province en
Québec
Province fr
Québec
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2008
Competition year année de concours
2006
Award amount
44250
Program id
RGPIN
Program nane en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
32
Committee name en
Cell Biology
Committee name fr
Biologie cellulaire
Area of application code
1200
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Advancement of knowledge
Area of application fr
Avancement des connaissances
Research subject code
5404
Research subject group en
Biochemistry
Research subject group fr
Biochimie
Research subject en
Enzymes
Research subject fr
Enzymes
Partie
3
Nb partie
5
Application title
the energetics of conformational interconversions plasminogen
Keyword
NA
Application summary
We study the blood protein, plasminogen. It is the body's first line of defense against unwanted, internal blood clots. It is also involved in tissue remodeling such as occurs during lactation and tumour metastasis. Plasminogen binds to a clot or cell, opens and can then be activated to plasmin, the enzymatic form. On binding, the plasminogen undergoes a large conformational change; it is part of the activation process. Our long term goal is to be able to activate plasminogen at will when it is desirable, and inhibit its activation when it is undesirable. In order to do that we need a firm grasp of the factors that dictate which conformations are present, when they are present and what promotes or inhibits their interconversion.
