Grant: Project Grant

Prostate cancer is the most prevalent cancer in men and a leading cause of cancer-related lethality. Consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality but the underlying mechanisms of this association are poorly understood. Considering the pandemic of diet-associated metabolic diseases and obesity, combined with the high frequency of newly diagnosed prostate cancers in developed countries, a thorough understanding of this link is urgent. Using an array of prostate cancer models representing clinically relevant subtypes of the disease, we will investigate how high-fat diet-induced obesity impact the reprograming of prostate cancer tumors and favors the development of a more aggressive disease. The overreaching goal is to identify and drug the Achilles heel of this diet-dependent tumor reprograming in order to impede prostate cancer progression and improve treatment options.