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Grant: Project Grant

Université de Sherbrooke

$3,021,752.00

OVATION-CEPEC: Optimal VAsopressor titraTION within the Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC)

FY 2025-26

Summary
Vasopressors are medicines that help raise blood pressure. Doctors often use them in emergency rooms, operating rooms, and intensive care units, especially for very sick patients whose blood pressure drops too low for different reasons. Interestingly, there isn't much strong evidence about how best to use these medicines, and some new studies suggest they might actually be more harmful than low blood pressure itself. Our earlier research, including work with international partners, has highlighted the need to better understand what vasopressors do overall. Now, we want to bring together scientists from Canada, the UK, Australia, and New Zealand to study how different blood pressure targets affect the use of vasopressors. This study will be part of the Canadian Critical Care platform, which tests common but not well-studied supportive treatments for critically ill patients.
Program
Project Grant
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database

As published

Id
533245
Name
Lamontagne Francois
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Randomized Controlled Trials 3
Projecttitle
OVATION-CEPEC: Optimal VAsopressor titraTION within the Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC)
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$3,021,752
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Randomized Controlled Trial; Supportive Care; Usual Care; Vasopressor Therapy
Abstract
Vasopressors are medicines that help raise blood pressure. Doctors often use them in emergency rooms, operating rooms, and intensive care units, especially for very sick patients whose blood pressure drops too low for different reasons. Interestingly, there isn't much strong evidence about how best to use these medicines, and some new studies suggest they might actually be more harmful than low blood pressure itself. Our earlier research, including work with international partners, has highlighted the need to better understand what vasopressors do overall. Now, we want to bring together scientists from Canada, the UK, Australia, and New Zealand to study how different blood pressure targets affect the use of vasopressors. This study will be part of the Canadian Critical Care platform, which tests common but not well-studied supportive treatments for critically ill patients.
Competitiondate
202509
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Lamontagne, Francois; Adhikari, Neill K; Slessarev, Marat
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $3,021,752~ $0~
Université de Sherbrooke - $3,021,752 Grant (2025-26) | Canada Spends