Grant: Project Grant
McMaster University
$1,014,410.00
Molecular mechanism of toxin export by the bacterial type VIIb secretion system
FY 2025-26
Summary
Many of the bacteria that make people sick release harmful toxins that not only damage a patient's cells but also kill the beneficial bacteria that live within them. Harmful bacteria such as Streptococcus release their toxins by using a specialized molecular syringe known as the type VII secretion system (T7SS). This proposal seeks to uncover how the T7SS molecular syringe operates at the molecular level. This detailed information is needed before rational strategies to disable the T7SS can be developed. Disabling the T7SS will prevent harmful bacteria from damaging healthy human cells while sparing the beneficial bacterial cells in our bodies that contribute to our well being.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
532059
Name
Whitney John
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - A
Projecttitle
Molecular mechanism of toxin export by the bacterial type VIIb secretion system
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$1,014,410
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bacterial Effector Proteins; Bacterial Genetics; Biochemistry; Molecular Biology; Protein Export In Bacteria; Structural Biology; Type Vii Secretion System
Abstract
Many of the bacteria that make people sick release harmful toxins that not only damage a patient's cells but also kill the beneficial bacteria that live within them. Harmful bacteria such as Streptococcus release their toxins by using a specialized molecular syringe known as the type VII secretion system (T7SS). This proposal seeks to uncover how the T7SS molecular syringe operates at the molecular level. This detailed information is needed before rational strategies to disable the T7SS can be developed. Disabling the T7SS will prevent harmful bacteria from damaging healthy human cells while sparing the beneficial bacterial cells in our bodies that contribute to our well being.
Competitiondate
202509
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Whitney, John
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,014,410~ $0~
