Grant: Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)
University of Ottawa
$499,890.00
Systems Analysis of novel small non-coding RNA in Stress-Induced Alterations in Transcription and Protein Translation: Towards novel Biomarkers and Therapeutics for Neurodegenerative Disorders (RNA-Neuro)
FY 2017-18
Summary
Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Parkinson's disease (PD) are progressive neurodegenerative disorders, but their disease progression can vary significantly between patients due to genetically heterogeneous backgrounds. Survival in ALS, for instance, ranges from less than 6 months to over 10 years in 5% of cases. The underlying mechanisms for these differences in disease progression are still poorly understood, but could provide key insights into disease mechanisms and deliver novel therapeutics.
Department
Program
Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
367900
Name
Slack Ruth S
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
German Federal Ministry of Research, Technology and Space (Berlin); Innovation Fund Denmark: Research, Technology and Growth (Denmark); The Netherlands Organization for Health Research and Development (ZonMw); Ministero della Salute (Italy); Science Foundation Ireland
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Special Cases
Projecttitle
Systems Analysis of novel small non-coding RNA in Stress-Induced Alterations in Transcription and Protein Translation: Towards novel Biomarkers and Therapeutics for Neurodegenerative Disorders (RNA-Neuro)
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$499,890
Cihrequipment2
$0
Programname2
Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)
Keyworddelim
Amyotrophic Lateral Sclerosis (Als); Frontotemporal Dementia; Parkinson'S Disease (Pd); Small Non-Coding Rna
Abstract
Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Parkinson's disease (PD) are progressive neurodegenerative disorders, but their disease progression can vary significantly between patients due to genetically heterogeneous backgrounds. Survival in ALS, for instance, ranges from less than 6 months to over 10 years in 5% of cases. The underlying mechanisms for these differences in disease progression are still poorly understood, but could provide key insights into disease mechanisms and deliver novel therapeutics.
Competitiondate
201706
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Slack, Ruth S
Approvedterm
3 ans 0 mois
Cihrcontribution2
Inst of Neurosc Mental Hlth &A~ $20,000~ $0~Institute of Aging~ $479,890~ $0~
