Grant: Operating Grant
University of Alberta
$710,226.00
Prion Protein Proteostasis
FY 2013-14
Summary
The prion protein called PrP is needed first as fuel to make misfolded proteins that cause disease and second in a role where the misfolded protein kills brain cells. Surprisingly we have now found that brain cells are "fighting back" in prion infections by reducing the amount of prion protein they make. We call this process down-regulation. We intend to understand how down-regulation works and to find ways to augment this natural process.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
304248
Name
Westaway David
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Cell Biology & Mechanisms of Disease
Projecttitle
Prion Protein Proteostasis
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$710,226
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Alzheimer'S; Metabolism; Prions; Proteases; Protein Folding; Proteostasis; Transgenics
Abstract
The prion protein called PrP is needed first as fuel to make misfolded proteins that cause disease and second in a role where the misfolded protein kills brain cells. Surprisingly we have now found that brain cells are "fighting back" in prion infections by reducing the amount of prion protein they make. We call this process down-regulation. We intend to understand how down-regulation works and to find ways to augment this natural process.
Competitiondate
201403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Westaway, David
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $710,226~ $0~
