Grant: Project Grant
Sunnybrook Research Institute (Toronto, Ontario)
$795,600.00
Ultrasound-Stimulated Microbubble Enhancement of Tumour Radiation Response
FY 2017-18
Summary
We have recently discovered that ultrasound-stimulated and microbubble-mediated endothelial cellular perturbation can significantly enhance the effectiveness of radiation therapy by 40-60 fold in vivo.
We will investigate the biology of the enhancement effect, here, by using chemical agents and genetic modification to modulate the gene pathways involved. The treatments will also be scaled up in larger animals and ultimately tested, for the first time, in cancer patients receiving radiotherapy.
The ultimate goal is to use this novel methodology for enhancing radiation treatments. This technology stands to change how radiation treatments are given. Furthermore, it has the potential to lower the total dose of radiation being administered in addition to making treatments more efficacious.
Department
Program
Project Grant
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
379633
Name
Czarnota Gregory J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Medical Physics & Imaging
Projecttitle
Ultrasound-Stimulated Microbubble Enhancement of Tumour Radiation Response
Programtype2
Operating Grants
Orgnameinp2
Sunnybrook Research Institute (Toronto, Ontario)
Cihramount2
$795,600
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Ceramide; Microbubble; Radiation; Radiation Enhancement; Ultrasound
Abstract
We have recently discovered that ultrasound-stimulated and microbubble-mediated endothelial cellular perturbation can significantly enhance the effectiveness of radiation therapy by 40-60 fold in vivo.
We will investigate the biology of the enhancement effect, here, by using chemical agents and genetic modification to modulate the gene pathways involved. The treatments will also be scaled up in larger animals and ultimately tested, for the first time, in cancer patients receiving radiotherapy.
The ultimate goal is to use this novel methodology for enhancing radiation treatments. This technology stands to change how radiation treatments are given. Furthermore, it has the potential to lower the total dose of radiation being administered in addition to making treatments more efficacious.
Competitiondate
201803
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Czarnota, Gregory J
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $795,600~ $0~
