Grant: Operating Grant - PA: Huntington's Society of Canada (Prize)
University of Alberta
$0.00
Cellular lipids in Huntington's disease
FY 2010-11
Summary
Huntington's disease (HD) is the most common inherited neurodegenerative disorder. It is characterized by progressive
motor dysfunction, cognitive decline and psychiatric disturbances. There is currently no cure for this disease. The production
of certain lipid molecules that are important for normal functioning of brain cells is impaired in HD. The aim of this proposal is
to investigate the consequences of reduced lipid synthesis in HD brain and to test whether restoring normal levels of these
important neural molecules improves HD symptoms and slows down disease progression. Supported by encouraging
preliminary results, our studies will potentially identify new therapeutic interventions for the cure of HD.
Department
Program
Operating Grant - PA: Huntington's Society of Canada (Prize)
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
241199
Name
Sipione Simonetta
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Huntington Society of Canada
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Cellular lipids in Huntington's disease
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$0
Cihrequipment2
$0
Programname2
Operating Grant - PA: Huntington's Society of Canada (Prize)
Keyworddelim
Animal Studies; Cell Biology; Cell Signaling; Gangliosides; Huntington'S Disease; Lipid Metabolism; Neurobiology
Abstract
Huntington's disease (HD) is the most common inherited neurodegenerative disorder. It is characterized by progressive
motor dysfunction, cognitive decline and psychiatric disturbances. There is currently no cure for this disease. The production
of certain lipid molecules that are important for normal functioning of brain cells is impaired in HD. The aim of this proposal is
to investigate the consequences of reduced lipid synthesis in HD brain and to test whether restoring normal levels of these
important neural molecules improves HD symptoms and slows down disease progression. Supported by encouraging
preliminary results, our studies will potentially identify new therapeutic interventions for the cure of HD.
Competitiondate
201103
Approvedterm2
1 yr 0 mth
Pinamesdelim
Sipione, Simonetta
Approvedterm
1 an 0 mois
