Grant: Project Grant
University of Alberta
$638,356.00
Fecal microbial transplantation in the management of patients with mild-to-moderate Crohn's disease
FY 2015-16
Summary
Patients who have Crohn's disease have different kinds of bacteria that are living in their intestine compared to healthy persons. Fecal microbial transplantation involves transplanting fecal material from a healthy person into a person with disease to change the bacterial profile to a more healthy profile. This clinical trial will determine if patients with Crohn's disease can be treated with fecal microbial transplants. Crohn's disease patients will be divided into two groups to receive either a fecal transplant or water (placebo) by colonoscopy. To follow disease activity, clinical symptoms will be followed over the next 12 weeks. Changes in gut bacteria and immune function will be followed in blood and stool samples. The knowledge gained from this study can be used to help develop new treatments for patients with Crohn's disease.
Department
Program
Project Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
346639
Name
Madsen Karen L
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Clinical
Prcname2
Project Grant Competition
Projecttitle
Fecal microbial transplantation in the management of patients with mild-to-moderate Crohn's disease
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$638,356
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Crohn'S Disease; Fecal Transplants; Microbiome
Abstract
Patients who have Crohn's disease have different kinds of bacteria that are living in their intestine compared to healthy persons. Fecal microbial transplantation involves transplanting fecal material from a healthy person into a person with disease to change the bacterial profile to a more healthy profile. This clinical trial will determine if patients with Crohn's disease can be treated with fecal microbial transplants. Crohn's disease patients will be divided into two groups to receive either a fecal transplant or water (placebo) by colonoscopy. To follow disease activity, clinical symptoms will be followed over the next 12 weeks. Changes in gut bacteria and immune function will be followed in blood and stool samples. The knowledge gained from this study can be used to help develop new treatments for patients with Crohn's disease.
Competitiondate
201603
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Madsen, Karen L; Fedorak, Richard N; Kao, Dina H; Kaplan, Gilaad G; Kroeker, Karen I
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $638,356~ $0~
