Grant: Project Grant - Priority Announcement: HIV/AIDS and STBBI
University of British Columbia
$100,000.00
Imaging, Molecular, and Clinical Biomarkers of Accelerated Lung Aging in People Living with Human Immunodeficiency Virus (AGE-HIV)
FY 2021-22
Summary
People living with HIV (PLWH) have a higher chance of developing lung disease similar to people who have smoked for a very long time. We believe that PLWH age faster than people without HIV and that this aging occurs in their lungs to increase their chance of having lung disease. We will use new imaging machines now available to look at what injuries PLWH have in their lungs. We will then use a procedure called a bronchoscopy to collect cells from these injured regions of the lung and use new techniques to look at their cells' makeup and behaviour down to each single cell. Finally, we will test whether some of these injury markers in the cell can help predict bad events in PLWH such as deaths and hospitalizations. Together, this information will allow us to see how PLWH age in their lungs and what the effects of this aging process are on the development of lung disease.
Department
Program
Project Grant - Priority Announcement: HIV/AIDS and STBBI
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
456163
Name
Leung Janice
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Respiratory System
Projecttitle
Imaging, Molecular, and Clinical Biomarkers of Accelerated Lung Aging in People Living with Human Immunodeficiency Virus (AGE-HIV)
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Project Grant - Priority Announcement: HIV/AIDS and STBBI
Keyworddelim
Biomarkers; Copd; Epigenetics; Hiv; Imaging; Transcriptomics
Abstract
People living with HIV (PLWH) have a higher chance of developing lung disease similar to people who have smoked for a very long time. We believe that PLWH age faster than people without HIV and that this aging occurs in their lungs to increase their chance of having lung disease. We will use new imaging machines now available to look at what injuries PLWH have in their lungs. We will then use a procedure called a bronchoscopy to collect cells from these injured regions of the lung and use new techniques to look at their cells' makeup and behaviour down to each single cell. Finally, we will test whether some of these injury markers in the cell can help predict bad events in PLWH such as deaths and hospitalizations. Together, this information will allow us to see how PLWH age in their lungs and what the effects of this aging process are on the development of lung disease.
Competitiondate
202109
Approvedterm2
1 yr 0 mth
Pinamesdelim
Leung, Janice
Approvedterm
1 an 0 mois
Cihrcontribution2
HIV/AIDS~ $80,000~ $0~Inst of Infection & Immunity~ $20,000~ $0~
