Grant: Project Grant
University of Toronto
$1,017,450.00
New insights into the development of metabolic dysfunction as a comorbidity in Crohn's disease.
FY 2023-24
Summary
Recent findings have uncovered a surprising link between patients with the inflammatory bowel disease, Crohn's disease (CD) and an increased risk of type 2 diabetes (T2D). Notably, CD and T2D share certain pathophysiological features in patients, including altered metabolism, accumulation of abdominal fat, an increased "leaky gut" and changes in the microbes that inhabit the gut, yet the relationship between these two diseases is not understood. We have developed a mouse model of CD featuring intestinal inflammation that promotes features of metabolic disease, similar to what is observed in T2D patients. With this model in hand, we can now study the pathogenesis of this complication of CD, which will help to shed light on mechanisms underlying intestinal health and open up new avenues for treatment.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
502045
Name
Philpott Dana J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Hematology, Digestive Disease & Kidney
Projecttitle
New insights into the development of metabolic dysfunction as a comorbidity in Crohn's disease.
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$1,017,450
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Crohn'S Disease; Intestinal Inflammation; Microbiome; Type 2 Diabetes
Abstract
Recent findings have uncovered a surprising link between patients with the inflammatory bowel disease, Crohn's disease (CD) and an increased risk of type 2 diabetes (T2D). Notably, CD and T2D share certain pathophysiological features in patients, including altered metabolism, accumulation of abdominal fat, an increased "leaky gut" and changes in the microbes that inhabit the gut, yet the relationship between these two diseases is not understood. We have developed a mouse model of CD featuring intestinal inflammation that promotes features of metabolic disease, similar to what is observed in T2D patients. With this model in hand, we can now study the pathogenesis of this complication of CD, which will help to shed light on mechanisms underlying intestinal health and open up new avenues for treatment.
Competitiondate
202403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Philpott, Dana J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,017,450~ $0~
