Grant: Team Gr.: Embracing Diversity to Achieve Precision/Health Equity -Gen. Omics-LOI

Non-communicable diseases, including cardiovascular disease, cancers, chronic respiratory disease, and diabetes, remain the leading causes of death in Canada. A large body of evidence suggests that primary and secondary prevention could significantly reduce morbidity and mortality, and reduce healthcare spending. Further, if prevention activities focused on populations made vulnerable by social and economic policies this could reduce health inequities.4 However, our approach to primary and secondary prevention is too often "one size fits all", and does not take advantage of our new understanding of how biological, social and genomic risks intersect, nor new approaches to process data. In PRECISE Primary Care, we will advance precision prevention in Canadian primary care. Our vision is of primary care systems that efficiently integrate biological data, social data and genomic data to provide tailored prevention plans. We will conduct a series of interrelated initiatives and projects: 1) foundational research on existing tools and data, and co-design new approaches to precision prevention with patients and providers; 2) develop and validate an improved tool for precision prevention that combines EMR, administrative, social and genomic data, and is built to evolve with new data; and 3) conduct an implementation evaluation of this new tool for prevention in a network of primary care clinics. Our team brings a strong focus on the social determinants of health and health equity. PRECISE will support a more efficient, effective and equitable approach to prevention in primary care, reducing the burden on providers and lead to early detection that is expected to decrease long-term healthcare costs.