Grant: Project Grant
Ottawa Hospital Research Institute
$1,309,680.00
Monoacylglycerol lipase (Mgll)-regulated 2-AG/eCBR signaling in feeding circuits controls adult neurogenesis
FY 2024-25
Summary
The continuous birth and integration of adult-born neurons is an important part of neuronal plasticity in the adult brain. The inability of adult neural stem/progenitor cells (NSPCs) to produce newborn neurons may dampen neuronal plasticity, increasing neuronal vulnerability. Numerous studies have highlighted innervated neuronal projections from distant brain regions
as an important niche component to modulate NSPC function. Thus, our current proposal aims to decipher the neuronal endocannabinoid signaling mechanisms that couple feeding control neuronal circuitry to NSPC behavior. This underlying mechanistic study will lead to understanding how energy metabolism neural control center where feeding control neurons reside regulates NSPC function and neuronal plasticity at the cellular, molecular and system levels.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
524045
Name
Wang Jing
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Monoacylglycerol lipase (Mgll)-regulated 2-AG/eCBR signaling in feeding circuits controls adult neurogenesis
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$1,309,680
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
2-Ag/Endocannabinoid Receptor Signaling; Hypothalamic Arcuate Nucleus; Monoacylglycerol Lipase; Neural Circuitry; Neuronal Differentiation; Odor-Reward Associative Memory; Olfactory Bulb Neurogenesis; Pomc Satiety Activating Neurons; Svz Neural Stem/Precursor Cell
Abstract
The continuous birth and integration of adult-born neurons is an important part of neuronal plasticity in the adult brain. The inability of adult neural stem/progenitor cells (NSPCs) to produce newborn neurons may dampen neuronal plasticity, increasing neuronal vulnerability. Numerous studies have highlighted innervated neuronal projections from distant brain regions
as an important niche component to modulate NSPC function. Thus, our current proposal aims to decipher the neuronal endocannabinoid signaling mechanisms that couple feeding control neuronal circuitry to NSPC behavior. This underlying mechanistic study will lead to understanding how energy metabolism neural control center where feeding control neurons reside regulates NSPC function and neuronal plasticity at the cellular, molecular and system levels.
Competitiondate
202503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Wang, Jing
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,309,680~ $0~
