Grant: Project Grant
University of British Columbia
$895,050.00
AI-supported mapping and probing of the regulation of cardiac voltage-gated calcium channels.
FY 2024-25
Summary
Channels in membranes of our cells play very important roles in a variety of processes relevant to our health. Calcium channels, for instance, regulate how much calcium enters a cell and, by doing so, help in the initiation of heart muscle contraction or in the transmission of information in the brain. We still have a limited understanding of how these channels function and how deficits in their working mechanisms can lead to various diseases including heart arrythmias and epilepsy. In the proposed work we will engineer and apply new computational and nanoscale technologies to elucidate how these channels work and explore whether AI-based protein design methods open up new therapeutic avenges for diseases that are caused by specific deficits of calcium channels.
Department
Program
Project Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
522448
Name
Gsponer Jörg
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Biomedical Engineering
Projecttitle
AI-supported mapping and probing of the regulation of cardiac voltage-gated calcium channels.
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$895,050
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Calcium Channels; Electrophysiology; Heart Cells; Machine Learning; Protein Engineering; Structural Biology; Structure Prediction; X-Ray Crystallography
Abstract
Channels in membranes of our cells play very important roles in a variety of processes relevant to our health. Calcium channels, for instance, regulate how much calcium enters a cell and, by doing so, help in the initiation of heart muscle contraction or in the transmission of information in the brain. We still have a limited understanding of how these channels function and how deficits in their working mechanisms can lead to various diseases including heart arrythmias and epilepsy. In the proposed work we will engineer and apply new computational and nanoscale technologies to elucidate how these channels work and explore whether AI-based protein design methods open up new therapeutic avenges for diseases that are caused by specific deficits of calcium channels.
Competitiondate
202503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Gsponer, Jörg
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $895,050~ $0~
